Endocrine Abstracts

Background: Central nervous insulin is critically involved in the regulation of body weight and memory processing. Long-term administration of intranasal insulin reduces body weight in men but not in women while improving hippocampus-dependent memory processing in both genders. Here, acute effects of intranasal insulin on food intake and memory functions were studied in men and women.Methods: Thirty-two healthy, normal-weight subjects (14 men, 18 women) ...

Background: Secretory activity of the hypothalamo-pituitary–adrenal (HPA) axis typically increases during the second half of nocturnal sleep. Assuming that this rise in ACTH and cortisol levels occurs in response to the negative energy balance induced by nocturnal fasting and concomitant increases in cerebral glucose consumption during REM sleep, we examined the effects of glucose infusion on nocturnal HPA axis activity during wake and sleep periods.<p class="abstext"...

Background: Sleep loss is increasingly common in the western world and has been shown to be associated with an increased risk of diabetes mellitus and obesity.Objective: We hypothesised that short term sleep loss results in a diabetogenic metabolic status during carbohydrate challenge at a breakfast buffet.Subjects and methods: Fifteen healthy, normal-weight young men were studied in randomized balanced order on the subsequent morn...

Background/Introduction: Diabetic ketoacidosis (DKA) is a severe complication of diabetes mellitus type 1 (T1DM) with potentially life-threatening course. Data on patient knowledge about DKA in German-speaking countries is rare. Thus, we aimed to gather data about T1DM patients’ knowledge in terms of DKA.Methods: Together with two T1DM patients and an experienced diabetes counselor, we developed an anonymous questionnaire covering general knowledge ...